! ACE Model for Power Calculations ! Simulated data ! Simulate the data ! 30% additive genetic (.5477ý=.3) ! 20% common environment (.4472ý=.2) ! 50% random environment (.7071ý=.5) G1: model parameters Data Calc NGroups=3 Begin Matrices; X Lower 1 1 Fixed ! genetic structure Y Lower 1 1 Fixed ! common environmental structure Z Lower 1 1 Fixed ! specific environmental structure End Matrices; Matrix X .5477 Matrix Y .4472 Matrix Z .7071 Begin Algebra; A= X*X' ; C= Y*Y' ; E= Z*Z' ; End Algebra; End G2: MZ twin pairs Data Calc NInput_vars=2 Matrices= Group 1 Covariances A+C+E | A+C _ A+C | A+C+E / Options MX%E=mzsim.cov End G3: DZ twin pairs Data Calc NInput_vars=2 Matrices= Group 1 H Full 1 1 Covariances A+C+E | H@A+C _ H@A+C | A+C+E / Matrix H .5 Options MX%E=dzsim.cov End ! Fit the wrong model to the simulated data G1: model parameters Data Calc NGroups=3 Begin Matrices; X Lower 1 1 Free ! genetic structure Y Lower 1 1 Fixed ! common environmental structure Z Lower 1 1 Free ! specific environmental structure End Matrices; Begin Algebra; A= X*X' ; C= Y*Y' ; E= Z*Z' ; End Algebra; End G2: MZ twin pairs Data NInput_vars=2 NObservations=1000 CMatrix Full File=mzsim.cov Matrices= Group 1 Covariances A+C+E | A+C _ A+C | A+C+E / Option RSiduals End G3: DZ twin pairs Data NInput_vars=2 NObservations=1000 CMatrix Full File=dzsim.cov Matrices= Group 1 H Full 1 1 Covariances A+C+E | H@A+C _ H@A+C | A+C+E / Matrix H .5 Start .5 All Options RSiduals Power= .05,1 ! .05 sig level & 1 df End