Viriginia Institute for Psychiatric and Behavioral Genetics

Graduate Courses

Mx class in Quantitative Genetics

Topics for Fall 2004 (Tuesdays from 12:45 to 3:45pm or Fridays from 9am to 12pm in the VIPBG Conference Room (Biotech I)
Text: Methodology for Genetic Studies of Twins and Families by Neale & Cardon, 1992 PDF of first revision of N&C book
Manual: Mx: Statistical Modeling by Neale, Boker, Xie & Maes, 2003 PDF of Mx manual

Date	Lecture Topic	Lecturer	Notes and Examples
10/19	Causes of variation/ Biometrical Genetics Path analysis/ Matrix algebra	Neale Maes	Introdoction PPT Introdoction PDF Path Analysis PPT Path Analysis PDF
10/26 12:45-3:45pm	Introduction to Mx (Graphical Interface) Fitting saturated models	Maes	Intro to Mx PPT Intro to Mx PDF saturated model diagram rectangular datafile MZ dat file DZ dat file saturated model script rectangular datafile dat file all example files zipped
11/2 12:45-3:45pm	Maximum likelihood / Goodness-of-fit Statistics Fitting univariate models	Neale Maes	Chapter in Neale & Cardon, 1992 Chapter in Little, Schnabel & Baumart, 2000 one locus example two locus example Univariate PPT Univariate PDF ACE model example rectangular datafile dat file ACE model + submodels ACE model + submodels 2 all example files zipped
11/12 9:00-12:00am	Gene x age/sex/environment interaction Testing for heterogeneity across sex/age	Maes	Heterogeneity PPT Heterogeneity PDF ACEf example SATf ACEm example SATm rec datafile dat file ACEfm4 SATfm example ACEfm5 all example files zipped
11/16 12:30-3:30pm	Multifactorial threshold model / Ascertainment Fitting models to categorical data	Neale Maes	Categorical PPT Categorical PDF Contingency Table Ordinal Frequency ord datafile dat file ACE categorical all example files zipped
11/23 12:30-3:30pm	Genetic models for correlated data Phenotypic factor analysis / Fitting bivariate models	Maes	Bivariate PPT Bivariate PDF Bivariate Example rec datafile dat file all example files zipped
11/30 12:30-3:30pm	Independent and common pathway models Fitting multivariate models	Maes	Multivariate PPT Multivariate PDF Multivariate Example rec datafile mz dat file dz dat file Independent Pathway Model Common Pathway Model all example files zipped
12/7 12:30-3:30pm	Developmental continuity and change OR Extended Pedigrees Fitting models to longitudinal data or extended pedigrees	Maes	Longitudinal PPT Longitudinal PDF Longitudinal Example rec datafile mz dat file dz dat file Simplex Model all example files zipped
12/14 1:30-4:30pm	Issues in study design & power Power Calculations & Simulation	Neale	Power PPT ace.mx dzsim.cov mzsim.cov power-raw.mx power.mx power.mx.old power.mxo power.ppt simulate.html simulate.nb trfmd.pdf
1/6 1:30-4:30pm	Methods for identifying QTL's QTL analysis	Neale	Linkage PPT qtl2.zip qtl.zip
1/13 1:30-4:30pm	Linkage and Association Models for linkage and assocation	Neale	Association PPT assoc.mx sim1.rec sim2.rec

information	mission | history | relations | contact	research	resources | projects | collaborations | publications | software
people	faculty | trainees | staff | jobs	education	seminars | training program | training record | courses | workshops

© 2000-2005 Virginia Institute for Psychiatric and Behavioral Genetics Home Questions, comments, suggestions, problems? Contact the Webmaster

Date last modified: August 31, 2005