NARSAD

Virginia Institute for Psychiatric and Behavioral Genetics

Using Biological haplotypes to identify susceptible genes for schizophrenia

Grant number
NARSAD

Principal Investigator:
Xiangning Chen

Co-investigators:

Years:
2002-2004

Abstract

In this application we proposed a new approach to identify susceptible haplotype for schizophrenia for the 5q22-31 linkage peak implicated in the genome scan study of the Irish high density schizophrenia families. The plan was to establish chromosome 5 specific hybrid haploid cell lines for a few families of the Irish subjects who were linked to the chromosome linkage peak. Genotyping these individual chromosomes would enable us to obtain biological haplotypes for these subjects. The biological haplotypes were then compared for the affected and unaffected to establish the risk haplotypes.

Funding Agency

NARSAD: National Alliance for Research on Schizophrenia & Affective Disorders

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