Viriginia Institute for Psychiatric and Behavioral Genetics
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Viriginia Institute for Psychiatric and Behavioral Genetics
| Graduate Courses |
Topics for Fall 2008 (Thursdays from 1 to 2:30pm and Fridays from 1 to 2:30pm in the VIPBG Conference Room (Biotech I))
Text: Methodology for Genetic Studies of Twins and Families by Neale & Cardon, 1992 revision
PDF of Neale & Maes boook
Manual: Mx: Statistical Modeling by Neale, Boker, Xie & Maes, 2006
PDF of Mx manual
| Date | Lecture Topic | Lecturer | Notes and Examples
| 8/28
| Causes of variation/ Biometrical Genetics
| Maes
| Introduction PPT Introduction PDF
| 9/4
| Path analysis | Matrix algebra Introduction to Mx Biometrical Genetics Maes
| Path Analysis PPT PDF
| Matrix Algebra PPT PDF Exercises Mx input Mx output Intro to Mx PPT PDF Biometrical Genetics PPT PDF 9/12 | 1-2:30 Summarizing data/ Univariate ACE model
| Fitting basic models Maes
| Saturated example files
| Univariate example files 9/12 | 2:30-4 Introduction to SEM
| Maximum likelihood / Goodness-of-fit Statistics Neale
| Individual Fit
Twin Analysis (Enc of Biostat)
| Twin Studies: Software (Enc HG) Software BG (Enc Beh Sc) Likelihood example One locus example Two locus example 9/18
| Univariate Genetic Analysis
| Fitting basic models Maes
| Univariate example files
Fill in the blanks exercise
| 9/25
| Multifactorial threshold model / Ascertainment
| Fitting models to categorical data Maes
| Threshold Models PPT PDF
Categorical Data PPT PDF
| Categorical example files Threshold Calculation 10/2
| Gene x age/sex/environment interaction
| Testing for heterogeneity across sex/age Maes
| Heterogeneity PPT PDF
| Heterogeneity example files 10/9
| Genetic models for correlated data
| Phenotypic FA / Fitting bivariate models Gillespie
| Bivariate PPT PDF
| Bivariate example files 10/16
| Independent and common pathway models
| Fitting multivariate models Maes
| Multivariate PPT PDF
| Multivariate example files 10/23
| Developmental continuity and change
| Fitting models to longitudinal data Gillespie
| Longitudinal PPT PDF
BGA2000 PPT BGA2001 PPT
| Developmental example files 10/30
| Issues in study design & power
| Power Calculations & Simulation Neale
| Power PPT PDF
| Power example files Power: Neale ea 94 Visscher 04 Visscher 08 EEA: Derks ea 06 11/6
| Extended Pedigrees
| Fitting models to extended kinships Maes
| Extended Pedigrees PPT PDF
| Extended Pedigrees example files 11/13
| Methods for identifying QTL's
| QTL analysis Dick
| Linkage and Association Intro PPT PDF
| 11/20
| Linkage and Association Analysis
| Fitting Linkage and Association Models Medland
| Linkage & Association PPT PDF
| Linkage and Association example files 12/4
| Item response Theory
| Fitting IRT Models Gillespie
| Item Response Theory example files
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