NARSAD

Virginia Institute for Psychiatric and Behavioral Genetics

Exploring the use of haplotype maps to detect susceptibility to schizophrenia

Grant number
NARSAD

Principal Investigator:
Edwin van den Oord

Co-investigators:

Years:
2002-2004

Abstract

The recent discovery of fairly simple haplotype structures in the human genome and research efforts to construct haplotype maps offer new possibilities for genome wide scans to detect susceptibility genes for schizophrenia. However, several methodological issues such as the generalizability of existing haplotype maps to our Irish samples and determination of optimal tag SNPs need more attention. To address these issues we propose a pilot study consisting of a small haplotype map based search to detect susceptibility genes for schizophrenia. Successful completion of this project means that we have a) learned how to use the haplotype map framework in an optimal and scientifically responsible manner, thereby paving the road for an efficient and powerful genome wide scan to detect find susceptibility genes for schizophrenia, and b) performed a small scan to detect susceptibility genes for schizophrenia.

Funding Agency

NARSAD: National Alliance for Research on Schizophrenia & Affective Disorders

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