Brien Patrick Riley

Virginia Institute for Psychiatric and Behavioral Genetics

Brien Patrick Riley

Assistant Professor
Department of Psychiatry and Human Genetics
Director of the Molecular Laboratory at VIPBG

Tel: 804 828 8083
Fax: 804 828 1471 Email:
bpriley@vcu.edu P.O. Box:
980424 VIPBG
Biotech 1-112

Education

1982-1986: BA in Psychology, Columbia College, Columbia University, New York
1992-1993: MSc in Human Nutrition, London School of Hygiene and Tropical Medicine, University of London
1993-1996: PhD, Department of Biochemistry and Molecular Genetics, St Mary's Hospital Medical School, Imperial College, London

Professional Experience

1983-1987: Data coder then research assistant with the VERA Institute of Justice, 377 Broadway, New York
1985-1986: Technician in the laboratory of Dr. Dennis Kelly, New York State Psychiatric Institute, Columbia University, New York
1986-1987: Technician in the laboratory of Dr. John Pintar, Department of Anatomy, College of Physicians and Surgeons, Columbia University, New York
1987-1991: Various employment in London, including workshop manager for public arts project and bicycle courier
1991-1993: Research Assistant in Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, Imperial College, London
1993-1996: Research Assistant (registered for PhD) with Professor Robert Williamson in Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, Imperial College, London
1996-1998: Post-doctoral research assistant with Professor Robin Murray in Department of Psychological Medicine, Institute of Psychiatry, London
1998-2001: MRC Fellow, Division of Psychological Medicine and MRC Centre for Social, Genetic and Developmental Psychiatry Research, and Lecturer, Division of Psychological Medicine, Institute of Psychiatry, London
2000-2001: Member, Executive Committee and Faculty, MRC Centre for Social, Genetic and Developmental Psychiatry Research, Institute of Psychiatry, London
2001-present: Director of Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics and Assistant Professor, Departments of Psychiatry and Human Genetics, Virginia Commonwealth University

Honors

1996: Edgar Lawley Travel Scholarship to visit Malaysia and Australia to set up new collaborative research projects
1999: Young Investigator Award to attend the International Congress on Schizophrenia Research, Santa Fe, NM
1996/1998/2000/2004: Young Scientist Awards to attend Biennial Winter Workshop on Schizophrenia, Davos, Switzerland/Crans-Montana, Switzerland
1999/2000/2001: Post-doctoral Scholarships to attend World Congress on Psychiatric Genetics,St. Louis, Missouri, 2001; Versailles, France, August, 2000; Monterey, California, October, 1999

Funded Research

R01 AA11408 Prescott (2002-2006) Co-I, NIH/NIMH/NIAAA: An Irish Affected Sib Pair Study of Alcohol Dependence
R01 MH41953 Kendler (1999-2009) PI, NIH/NIMH: The Genetic Epidemiology of Schizophrenia in Ireland
R01 MH62276 Levinson (2000-2008) Co-I, NIH/NIMH: Multicenter Genetic Studies of Schizophrenia: Collaborative, Multicenter Replication Study of Linkage Findings in Schizophrenia from Chromosomes 15q, 18p and 22q.
ADW Riley (2002-2004) PI, AD Williams Trust Grant: Candidate Gene Studies of Anorexia Nervosa
NARSAD 2003 Young Investigator Award: Candidate gene studies of schizophrenia in family and trio samples from Ethiopia and South Africa
R01 MH068881: Collaborative full genome scan and association follow-up of a multi-center sample of 800 multiplex, narrow diagnosis schizophrenia pedigrees
Medical Research Council Research Training Fellowship: High resolution mapping, polymorphism, mutation and novel gene identification in the nicotinic acetylcholine receptor alpha 7 subunit (CHRNA7) gene region, chromosome 15q13-q14
Wellcome Trust Biomedical Research Collaboration: Sampling schizophrenic patients and their parents in Ethiopia and Ghana for molecular genetic analysis using transmission disequilibrium and trimmed haplotype analysis

Research Interests

Schizophrenia: Haplotype block structure and risk haplotype identification studies of the dystrobrevin binding protein 1 (DTNBP1) gene in 270 multiplex pedigrees, sequencing risk haplotypes, variation map construction, targeted expression studies; Linkage disequilibrium and association studies of additional linkage regions; Collaborative multi-center linkage studies of schizophrenia; Sample collection in Ethiopia and Ghana.
Ethanol dependence: Genome scan and candidate gene studies in sample of 1500 alcoholics.
Conduct disorder: Association studies of the monoamine oxidase (MAO) gene region with conduct disorder.
Autism: Develop collaborations and sampling center network for genetic studies of response to applied behaviour analysis (ABA) therapy.
Adolescent Depression: Develop strategies and collaborative links for direct identification of candidate genes explaining differences between males and females in risk for depression.
Turner syndrome: Studies of functional differences between monosomic TS cases with X chromosomes of maternal or paternal origin.

Selected Publications

SEARCH on PubMed site for most recent publications
Publications by VIPBG faculty
NIH Biosketch (in PDF format) updated April, 2004
NIH Biosketch (in PDF format, font Times Roman) updated May, 2003

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