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Faculty
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Brien Patrick Riley
Assistant Professor
Department of Psychiatry and Human Genetics
Director of the Molecular Laboratory at VIPBG
Tel: 804 828 8083
Fax: 804 828 1471
| Email:
bpriley@vcu.edu
| P.O. Box:
980424
| VIPBG
Biotech 1-112
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Dr. Riley has nearly 20 years experience in studies of psychiatric and other complex phenotypes. His broad area of research is the genetics, molecular
genetics and genomics of schizophrenia, alcohol dependence, autism and complex traits in general. Current work in the Riley lab includes genomewide
association (GWAS) and copy number variation studies, targeted next-generation sequencing, gene-gene and gene-environment interaction, networks and
pathways in schizophrenia and alcohol dependence and genetic determinants of treatment outcomes. Projects in planning stages include large sample alcohol
challenge data collection for studies using multiple “omics’ platforms and work in movement and neurological disorders. Dr. Riley works with an
international group of colleagues including key collaborators at Trinity College Dublin and Queens University Belfast, the Lieber Institute at Johns
Hopkins and numerous other institutions. The lab group includes post-docs, pre-docs, masters students and technicians.
Education
- 1982-1986: BA in Psychology, Columbia College, Columbia University, New York
- 1992-1993: MSc in Human Nutrition, London School of Hygiene and Tropical Medicine, University of London
- 1993-1996: PhD, Department of Biochemistry and Molecular Genetics, St Mary's Hospital Medical School, Imperial College, London
Professional Experience
- 1983-1987: Data coder then research assistant with the VERA Institute of Justice, 377 Broadway, New York
- 1985-1986: Technician in the laboratory of Dr. Dennis Kelly, New York State Psychiatric Institute, Columbia University, New York
- 1986-1987: Technician in the laboratory of Dr. John Pintar, Department of Anatomy, College of Physicians and Surgeons, Columbia University, New York
- 1987-1991: Various employment in London, including workshop manager for public arts project and bicycle courier
- 1991-1993: Research Assistant in Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, Imperial College, London
- 1993-1996: Research Assistant (registered for PhD) with Professor Robert Williamson in Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, Imperial College, London
- 1996-1998: Post-doctoral research assistant with Professor Robin Murray in Department of Psychological Medicine, Institute of Psychiatry, London
- 1998-2001: MRC Fellow, Division of Psychological Medicine and MRC Centre for Social, Genetic and Developmental Psychiatry Research, and Lecturer, Division of Psychological Medicine, Institute of Psychiatry, London
- 2000-2001: Member, Executive Committee and Faculty, MRC Centre for Social, Genetic and Developmental Psychiatry Research, Institute of Psychiatry, London
- 2001-present: Director of Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics and Assistant Professor, Departments of Psychiatry and Human Genetics, Virginia Commonwealth University
Honors
- 1996: Edgar Lawley Travel Scholarship to visit Malaysia and Australia to set up new collaborative research projects
- 1999: Young Investigator Award to attend the International Congress on Schizophrenia Research, Santa Fe, NM
- 1996/1998/2000/2004: Young Scientist Awards to attend Biennial Winter Workshop on Schizophrenia, Davos, Switzerland/Crans-Montana, Switzerland
- 1999/2000/2001: Post-doctoral Scholarships to attend World Congress on Psychiatric Genetics,St. Louis, Missouri, 2001; Versailles, France, August, 2000; Monterey, California, October, 1999
Funded Research
- 5R01MH083094: A Genome-wide Association Study of Schizophrenia in Ireland [08-12] PI: Brien Riley
- 1P20AA017828: Project 2: Cross Species Characterization of Gene Networks in Acute Responses [10-11] PI: Brien Riley
Research Interests
- Schizophrenia:
Haplotype block structure and risk haplotype identification studies of the dystrobrevin binding protein 1 (DTNBP1) gene in 270 multiplex pedigrees, sequencing risk haplotypes,
variation map construction, targeted expression studies; Linkage disequilibrium and association studies of additional linkage regions; Collaborative multi-center linkage studies of
schizophrenia; Sample collection in Ethiopia and Ghana.
- Ethanol dependence:
Genome scan and candidate gene studies in sample of 1500 alcoholics.
- Conduct disorder:
Association studies of the monoamine oxidase (MAO) gene region with conduct disorder.
- Autism:
Develop collaborations and sampling center network for genetic studies of response to applied behaviour analysis (ABA) therapy.
- Adolescent Depression:
Develop strategies and collaborative links for direct identification of candidate genes explaining differences between males and females in risk for depression.
- Turner syndrome:
Studies of functional differences between monosomic TS cases with X chromosomes of maternal or paternal origin.
Selected Publications
Copyright © 2011
Virginia Commonwealth University | School of Medicine | Virginia Institute for Psychiatric and Behavioral Genetics
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